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Author information Article notes Copyright and License information Disclaimer. Journal List Biomed Opt Express v. Finally, we demonstrate the use of the AnCam in time-lapse imaging of acetic acid-induced changes of the anal canal to show the dynamic changes resulting from the use of acetic acid on the epithelium as well as the reproducibility of the serial images. Lastly, the exam is charted manually. This image can then be remotely transferred to specialized centers where experienced professionals can interpret it for the screening of potential anal dysplasia. The current gold standard for anal cancer screening is high resolution anoscopy HRA , a technique adapted from standard cervical examination protocols [ 4 — 7 ]. All of the components of the imaging module were then realigned and mounted onto an axis, and fixed inside a polycarbonate tube with a

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However, there was no further change after the third staining Fig.

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Due to its simplicity and minimally invasive nature compared with HRA, the AnCam can also be suitable for regular preventive screenings among populations of patients with sexually transmitted diseases or male homosexual contact for the early diagnosis of HPV infection or anal cancer. Our AnCam system design and prototype are shown in Fig. It is worth noting that the morphologies of the stained tissue do not appear completely similar in the AnCam images compared with the HRA images, as shown in Fig. Lastly, the exam is charted manually.

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